London has lost top spot in the list of the world’s most innovative cities.

The UK capital was usurped at the summit of the 2018 Innovation Cities Index by Tokyo in Japan while Silicon Valley in California climbed above New York to sit third. Los Angeles rounded out the top five.

Data firm 2thinknow compiled the list after scoring cities on three key factors: cultural assets, human infrastructure and networked markets.

They also assessed the locations against 31 segments in their industries and economy as well as 162 indicators for innovation.

The other UK city to make the top 50 was Manchester, which jumped 11 places to 34th and is ranked higher than Chinese cities Shanghai and Beijing as well as Spanish capital Madrid.

London is a world leader in tech and ideas while Manchester is home to the largest creative, digital and technology cluster outside the capital.

Publication of the list follows the announcement that Amazon will establish operations in Manchester, creating 600 highly-skilled 'Silicon Valley' style jobs in early 2019, as well as expanding operations in Scotland and Cambridge.

TalkTalk is also relocating its headquarters to Greater Manchester while intelligence and security organisation GCHQ will establish a major base there too.

The only other UK cities to make the top 100 were Edinburgh (89th) and Glasgow (95th).

To see how the others fared, check out the top 500 here.